Finite-sample error-rate control and power guarantees under the linear subspace model
Sourced from the work of Amitay Eldar, Keren Mor Waknin, Samuel Davenport, Tamir Bendory, Armin Schwartzman, Yoel Shkolnisky
§ Problem Statement
Setup
Let with . Let be a known -dimensional linear subspace, and fix an orthonormal basis matrix so . Observe a 1D signal generated by
where is unknown, are unknown object locations, are unknown object shapes, inserts a length- vector into coordinates (zero elsewhere), and . Assume a non-overlap/separation condition such as for , and a minimum signal strength condition for all .
For each candidate location , define the local hypothesis
Let be the true object set and be the detection set returned by the specific procedure of Eldar-Mor Waknin-Davenport-Bendory-Schwartzman-Shkolnisky (with either its FWER-control or mFDR-control mode). Define , , , and
Unsolved Problem
Problem 2024. Prove non-asymptotic, explicit finite-sample guarantees for this concrete procedure, namely bounds of the form
together with an explicit finite-sample power guarantee
where are given quantitatively (ideally ) as functions of , under fully stated assumptions on the Gaussian noise law and signal geometry.
See Eldar et al. (2024) for further context.
§ Discussion
§ Significance & Implications
This closes the gap between asymptotic theory and practical operating regimes, where cryo-EM datasets are finite and often highly noisy. Quantitative finite-sample guarantees are essential for principled parameter tuning and for comparing detection methods in realistic experimental settings. See Eldar et al. (2024) for details.
§ Known Partial Results
Eldar et al. (2024): According to the abstract, the method is asymptotically guaranteed to detect all objects while controlling FWER or mFDR. Numerical simulations indicate strong non-asymptotic behavior, but no explicit finite-sample theorem is stated in the abstract.
§ References
Object detection under the linear subspace model with application to cryo-EM images
Amitay Eldar, Keren Mor Waknin, Samuel Davenport, Tamir Bendory, Armin Schwartzman, Yoel Shkolnisky (2024)
Annals of Statistics (to appear)
📍 Section 5 (Conclusions and future research), paragraph outlining open problems on finite-sample error-rate control.
Source paper where this problem appears.